This review paper explores the transformative integration of artificial intelligence (AI) and nanotechnology in DENTAL prosthetics, emphasizing their combined potential to enhance patient-specific outcomes in prosthodontics. Nanotechnology enables the fabrication of DENTAL prostheses that closely mimic natural teeth, while AI utilizes machine learning and neural networks to optimize diagnostic imaging, treatment planning, and PROSTHESIS customization. This synergy reduces clinical time and improves therapeutic success. The paper addresses current clinical demands for personalized DENTAL care, highlighting how AI-driven analysis of patient data, combined with advanced nanomaterials, meets these needs. Despite promising progress, challenges such as limited high-quality data for AI training, high initial costs, and technical complexity limit widespread clinical adoption. This review outlines the rationale, scope, and challenges of integrating AI and nanotechnology in DENTAL prosthetics, providing a comprehensive overview of this innovative approach.